【个人简介】：
        丁楅(bi)森，beat365华西二院/生物治疗全国重点实验室研究员，生命科学院副院长, 长江特聘教授，杰青，博士生导师

      
        1996-2000  南京大学         学士
        2000-2003  南京大学         硕士研究生
        2003-2008  美国宾夕法尼亚大学(UPenn)医学院    博士
        2008-2013  美国霍华德休斯医学研究所 (HHMI)    博士后
        2013-2016  美国康奈尔大学医学院    助理教授 (终身路径)
        2016-present beat365生物治疗国重/华西二院 研究员

【研究方向】:
        1）肺和肝等器官的再生和纤维化（结疤）反应。
        2）血管旁分泌(Angiocrine)功能对器官修复的调控。
        3) 开发新药靶向血管Angiocrine功能，促进器官再生并防止纤维化（结疤）。

【招生方向】：
        药学，生物化学，细胞生物学，生物工程，生物治疗等。

【代表性论著】：

1) Cao Z*, Lis R, Ginsburg M, Chavez D, Shido K, Rabbany SY, Fong GH, Sakmar TP, Rafii S*, Ding BS*. Targeting of pulmonary capillary vascular niche promotes lung alveolar repair and ameliorates fibrosis. Nature Medicine 2016; 22(2):154-62. (Journal Cover) (*Corresponding author). PMID 26779814

Highlighted in 1) Science Signaling 2016; 9(415):ec31; 2) Nature Review of Drug Discovery 2016; doi: 10.1038/nrd.2016.25

2) Rafii S*, Butler JM*, Ding BS*. Angiocrine functions of organ-specific endothelial cells Nature 2016; 529(7586):316-25. (*Corresponding author). PMID 26791722

3) Mo C, Li H, Yan M, Xu S, Wu J, Li J, Yang X, Li Y, Yang J, Su X, Liu J, Wu C, Wang Y, Dong H, Chen L, Dai L, Zhang M, Pu Q, Yang L, Ye T, Cao Z, Ding BS*. Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis. Cell Metabolism 2024;36(8):1839-1857. (*Lead corresponding author). PMID 39111287.

4) Ma J, Zhang L, Zhang X, Zhang L, Zhang H, Zhu Y, Huang X, Wang Y, Chen L, Qiang Pu*, Yang L*, Cao Z*, Ding BS*. Inhibiting endothelial Rhoj blocks pro-fibrotic vascular intussusception and angiocrine factors to sustain lung regeneration. Science Translational Medicine 2024;16(762):eado5266. (Journal Cover) (*Corresponding author). PMID 39196961

5) Zhang H, Ma Y, Cheng X, Wu D, Huang X, Chen B, Ren Y, Jiang W, Tang X, Bai T, Chen Y, Zhao Y, Zhang C, Xiao X, Liu J, Deng Y, Ye T, Chen L, Liu HM, Friedman SL, Chen L, Ding BS*, Cao Z*. Targeting epigenetically maladapted vascular niche alleviates liver fibrosis in nonalcoholic steatohepatitis. Science Translational Medicine 2021; 13(614):eabd1206. (* Corresponding author). PMID: 34613814

6) Chen Y, Pu Q, Ma Y, Zhang H, Ye T, Zhao C, Huang X, Ren Y, Qiao L, Liu H, Esmon C, Ding BS*, Cao Z*. Aging Reprograms the Hematopoietic-Vascular Niche to Impede Regeneration and Promote Fibrosis. Cell Metabolism 2021; 33:395-410. (Journal Cover) (* Senior author). PMID: 33357457

7) Ding BS*, Yang D, Swendeman SL, Christoffersen C, Neilsen LB, Friedman SL, Powell CA, Hla T, Cao Z*. Aging suppresses Sphingosine-1-Phosphate Chaperone ApoM in Circulation Resulting in Maladaptive Organ Repair. Developmental Cell 2020; 22; 53(6) 677690. (* Corresponding author). PMID 32544390

Highlighted in Developmental Cell 2020; 53(6):625-626. PMID: 32574591

8) Cao Z*, Ye T, Sun Y, Ji G, Shido K, Chen Y, Luo L, Na F, Li X, Huang Z, Ko, JL, Mittal V, Qiao L, Chen C, Martinez FJ, Rafii S, Ding BS*. Targeting the vascular and perivascular niches as a regenerative therapy for lung and liver fibrosis. Science Translational Medicine 2017; 9(405). pii: eaai8710. doi: 10.1126/scitranslmed.aai8710. (*Corresponding author).  PMID 28855398

9) Rafii S, Cao Z, Lis R, Chavez D, Shido K, Rabbany SY, Ding BS*. Platelet-derived SDF-1 primes the pulmonary capillary vascular niche to drive lung alveolar regeneration. Nature Cell Biology 2015; 17(2):123-36. (*Corresponding author). PMID 25621952

10) Ding BS*, Cao Z, Lis R, Nolan DJ, Guo P, Simons M, Penfold M, Shido K, Rabbany SY, and Rafii, S*. Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis. Nature 2014; 505(7481):97-102 (ePub 2013 Nov 20). (* Corresponding author).  PMID 24256728

Highlighted in 1) Science Signaling 2014; 7(307):ec7; 2) F1000 Prime (article 718183961); 3) Science Translational Medicine 2014; 6(224):ec33.

11) Cao Z*, Scandura JM, Inghirami GG, Shido K, Ding BS*, Rafii S*. Molecular Checkpoint Decisions Made by Subverted Vascular Niche Transform Indolent Tumor Cells into Chemoresistant Cancer Stem cells. Cancer Cell 2017; 31(1):110-126.

(* Corresponding author).  PMID 27989801

12) Cao Z, Ding BS*, Guo P, Lee SL, Butler JM, Casey SC, Simons M, Tam W, Felsher DW, Shido K, Scandura JM, Rafii, S*. Angiocrine signals from tumor vascular niche induce B-Cell lymphoma invasiveness and chemoresistance. Cancer Cell 2014; 25(3): 1-16. (* Corresponding author). PMID 24651014

Highlighted in 1) Cancer Cell 2014; 25, 261–263; 2) Nature Reviews Cancer 2014; doi:10.1038/nrc3730; 3)  Science Signaling 2014; 7: p. ec85

13) Ding BS, Nolan DJ, Guo P, Babazadeh AO, Cao Z, Rosenwaks Z, Sato TN, Shido K, Rabbany SY, Rafii S. Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization. Cell 2011; 147:539-553. PMID 22036563      

Highlighted in Cell 2011; 147(3):485-7

14) Ding BS, Nolan DJ, Butler JM, James D, Babazadeh AO, Rosenwaks Z, Mittal V, Kobayashi H, Shido K, Lyden D, Sato TN, Rabbany SY, & Rafii S. Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration. Nature 2010; 468(7321):310-5. PMID 21068842

【联系方式】：

Email: dingbisen@scu.edu.cn